Two people were killed and nine were wounded on Saturday evening, when security forces fired tear gas and birdshot to disperse about 1,000 protesters who attempted to enter Tahrir Square — the symbolic heart of the revolt that ousted Mubarak.
Security forces closed a Cairo metro station, the state news agency said, an apparent effort to prevent gatherings downtown.
Clashes also erupted at Zagazig University in the Nile Delta, and the state-owned Al-Ahram newspaper said 11 students were detained after setting fire to a building.
Many Egyptians who lived through the rule of former air force officer Mubarak view it as a period of autocracy and crony capitalism.
His overthrow led to Egypt’s first free election. But the winner, Mohamed Mursi, was ousted last year by Abdel Fattah al-Sisi, another military officer who won a presidential vote in May.
Egyptian authorities have since jailed Mursi and thousands of his Muslim Brotherhood supporters, sentencing hundreds to death in mass trials that drew international criticism.
By contrast, Mubarak-era figures have been released and new laws curtailing political freedoms have raised fears among activists that the old leadership is back.
“Down with Hosni Mubarak, down with every Mubarak, down with military rule” said one Facebook page that called for protests against the ruling.